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David E Jane Selected Research

Epilepsy (Aura)

12/2021Pharmacological characterization of a novel negative allosteric modulator of NMDA receptors, UBP792.
11/2021Synthesis and pharmacological characterisation of arctigenin analogues as antagonists of AMPA and kainate receptors.
6/2015Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators.
4/2013Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.
9/2012Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors.
12/2010Mapping the ligand binding sites of kainate receptors: molecular determinants of subunit-selective binding of the antagonist [3H]UBP310.
12/2010A novel family of negative and positive allosteric modulators of NMDA receptors.

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David E Jane Research Topics

Disease

7Epilepsy (Aura)
12/2021 - 12/2010
4Nervous System Diseases (Neurological Disorders)
06/2015 - 05/2009
3Schizophrenia (Dementia Praecox)
10/2017 - 12/2010
2Mental Disorders (Mental Disorder)
01/2019 - 11/2013
2Neurodegenerative Diseases (Neurodegenerative Disease)
06/2015 - 09/2012
2Chronic Pain
06/2015 - 12/2010
1Alzheimer Disease (Alzheimer's Disease)
06/2015
1Neuralgia (Stump Neuralgia)
09/2012
1Thrombotic Stroke
10/2011
1Glioma (Gliomas)
12/2010
1Pain (Aches)
12/2010
1Stroke (Strokes)
12/2010
1Amnesia (Dissociative Amnesia)
03/2006

Drug/Important Bio-Agent (IBA)

4N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA
01/2019 - 12/2010
2Glutamic Acid (Glutamate)FDA Link
06/2015 - 11/2013
2LigandsIBA
04/2013 - 12/2010
2Kainic Acid Receptors (Kainate Receptor)IBA
12/2010 - 03/2006
1Neuroprotective AgentsIBA
12/2021
1arctigeninIBA
11/2021
1Neurotransmitter Agents (Neurotransmitter)IBA
06/2015
1CoumarinsIBA
09/2012
1GluN2C-2D antagonist UBP145IBA
10/2011
1Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA
12/2010
1Glutamate Receptors (Glutamate Receptor)IBA
05/2009